(19)

(11)

EP 1 758 989 A2

(12)

(88) Date of publication A3: 02.03.2006 (43) Date of publication: 07.03.2007 Bulletin 2007/10 (21) Application number: 05723204.3 (22) Date of filing: 16.02.2005

(51) International Patent Classification (IPC):  C12N 5/16(2006.01) A61K 35/12(2006.01) C12N 5/22(2006.01) (86) International application number: PCT/US2005/005052 (87) International publication number: WO 2005/123123 (29.12.2005 Gazette 2005/52)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 08.06.2004 US 864788 15.07.2004 US 588146 P (71) Applicant: PrimeGen Biotech LLC Irvine, CA 92618 (US)	(72) Inventors: SAYRE, Chauncey, B. Irvine, CA 92606 (US) SILVA, Francisco, J. Rancho Cucamonga, CA 91730 (US) (74) Representative: Green, Mark Charles  Urquhart-Dykes & Lord LLP 30 Welbeck Street London W1G 8ER London W1G 8ER (GB)