(19)

(11)

EP 1 759 015 A2

(12)

(88) Date of publication A3: 04.05.2006 (43) Date of publication: 07.03.2007 Bulletin 2007/10 (21) Application number: 05762562.6 (22) Date of filing: 21.06.2005

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) (86) International application number: PCT/US2005/022030 (87) International publication number: WO 2006/002221 (05.01.2006 Gazette 2006/01)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 21.06.2004 US 582038 P 29.10.2004 US 623363 P (71) Applicant: Applera Corporation, Applied Biosystems Group Foster City, CA 94404-1128 (US)	(72) Inventors: LEE, Linda, G. Palo Alto, CA 94306 (US) SUN, Hongye San Mateo, CA 94404 (US) (74) Representative: Roques, Sarah Elizabeth  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)