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EP 1 765 313 A2

(12)

(88) Date of publication A3: 13.07.2006 (43) Date of publication: 28.03.2007 Bulletin 2007/13 (21) Application number: 05791104.2 (22) Date of filing: 24.06.2005

(51) International Patent Classification (IPC):  A61K 31/00(2006.01) A61K 45/06(2006.01) A61P 37/08(2006.01) A61P 31/14(2006.01) A61P 31/22(2006.01) A61P 25/02(2006.01) A61K 31/517(2006.01) A61P 37/04(2006.01) A61P 35/00(2006.01) A61P 31/18(2006.01) A61P 11/06(2006.01) (86) International application number: PCT/US2005/022769 (87) International publication number: WO 2006/002422 (05.01.2006 Gazette 2006/01)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 24.06.2004 US 582654 P 14.07.2004 US 588096 P 22.07.2004 US 590459 P 05.08.2004 US 599717 P 05.08.2004 US 599592 P 11.08.2004 US 600850 P 19.08.2004 US 603001 P 23.08.2004 US 603867 P 21.09.2004 US 612070 P 30.09.2004 US 614963 P (71) Applicant: Novartis Vaccines and Diagnostics, Inc. Emeryville, CA 94608-2916 (US)

(72) Inventors: VALIANTE, Nicholas M/S R338 Emeryville, CA 94608-2916 (US) XU, Feng M/S R338 Emeryville, CA 94608-2916 (US) (74) Representative: Marshall, Cameron John et al Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)