(19)

(11)

EP 1 773 243 A1

(12)

(43) Date of publication: 18.04.2007 Bulletin 2007/16 (21) Application number: 05762364.7 (22) Date of filing: 25.06.2005

(51) International Patent Classification (IPC):  A61F 2/06(2006.01) A61F 2/24(2006.01) A61L 27/54(2006.01) (86) International application number: PCT/US2005/022541 (87) International publication number: WO 2006/012322 (02.02.2006 Gazette 2006/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 29.06.2004 US 880043 (71) Applicant: THE CLEVELAND CLINIC FOUNDATION Cleveland, OH 44195 (US)	(72) Inventors: SARAC, Timur, Paul Orange Village, OH 44022 (US) SMEDIRA, Nicholas, G. Moreland Hills, OH 44022 (US) (74) Representative: Naismith, Robert Stewart et al Marks & Clerk Scotland 19 Royal Exchange Square Glasgow, G1 3AE Scotland Glasgow, G1 3AE Scotland (GB)