(19)

(11)

EP 1 776 481 A2

(12)

(88) Date of publication A3: 18.01.2007 (43) Date of publication: 25.04.2007 Bulletin 2007/17 (21) Application number: 05803634.4 (22) Date of filing: 11.08.2005

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) (86) International application number: PCT/US2005/028664 (87) International publication number: WO 2006/020824 (23.02.2006 Gazette 2006/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 11.08.2004 US 601036 P (71) Applicant: Yale University New Haven, CT 06511 (US)	(72) Inventors: KAHN, Jeffrey, S. Woodbridge, CT 06525-1100 (US) ESPER, Frank Solon, OH 44139 (US) (74) Representative: Gates, Marie Christina Esther et al c/o Tomkins & Co. 5 Dartmouth Road Dublin 6 Dublin 6 (IE)