(19)

(11)

EP 1 778 140 A2

(12)

(88) Date of publication A3: 16.03.2006 (43) Date of publication: 02.05.2007 Bulletin 2007/18 (21) Application number: 05768166.0 (22) Date of filing: 24.06.2005

(51) International Patent Classification (IPC):  A61F 7/12(2006.01) A61M 16/10(2006.01) (86) International application number: PCT/EP2005/007122 (87) International publication number: WO 2006/002949 (12.01.2006 Gazette 2006/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 25.06.2004 EP 04076879 (71) Applicant: Produvation BV 2333 AL Leiden (NL)	(72) Inventors: VAN HOLST, Gerrit, Jan NL-1602 KB Enkhuizen (NL) DE HAAN, Petrus, Theodorus NL-2343 RR Oestgeest (NL) (74) Representative: Sanderson, James L.C. et al Sanderson & Co., 34, East Stockwell Street Colchester, Essex CO1 1ST Colchester, Essex CO1 1ST (GB)