(19)
(11) EP 1 778 206 A2

(12)

(88) Date of publication A3:
15.06.2006

(43) Date of publication:
02.05.2007 Bulletin 2007/18

(21) Application number: 05806407.2

(22) Date of filing: 22.08.2005
(51) International Patent Classification (IPC): 
A61K 31/075(2006.01)
A61K 31/495(2006.01)
C07C 43/02(2006.01)
C07D 413/02(2006.01)
 A61K 31/47(2006.01)
A61K 31/5375(2006.01)
C07D 217/00(2006.01)
(86) International application number:
PCT/US2005/029634
(87) International publication number:
WO 2006/023778 (02.03.2006 Gazette 2006/09)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated Extension States:
AL BA HR MK YU

(30) Priority: 20.08.2004 US 603411 P

(71) Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Ann Arbor, MI 48109-8202 (US)

(72) Inventors:
  • WANG, Shaomeng
    Saline, MI 48176 (US)
  • WANG, Guoping
    Ann Arbor, MI 48105 (US)
  • TANG, Guozhi
    Ann Arbor, MI 48105 (US)
  • WANG, Renxiao
    Ann Arbor, MI 48108 (US)
  • NIKOLOVSKA-COLESKA, Zaneta
    Ann Arbor, MI 48105 (US)
  • WANG, Dajon
    Rockville, MD 20850 (US)
  • XU, Liang
    Ann Arbor, MI 48103 (US)

(74) Representative: Glawe, Delfs, Moll 
Patentanwälte Rothenbaumchaussee 58
20148 Hamburg
20148 Hamburg (DE)

   


(54) SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF