(19)

(11)

EP 1 781 259 A2

(12)

(88) Date of publication A3: 15.06.2006 (43) Date of publication: 09.05.2007 Bulletin 2007/19 (21) Application number: 05764429.6 (22) Date of filing: 16.06.2005

(51) International Patent Classification (IPC):  A61K 9/20(2006.01) (86) International application number: PCT/US2005/021707 (87) International publication number: WO 2006/023035 (02.03.2006 Gazette 2006/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 28.07.2004 WO PCT/US2004/024485 (71) Applicant: MALLINCKRODT, INC. St. Louis Missouri 63134 (US)	(72) Inventors: HEIDER, Todd, P. Imperial, MO 63052 (US) WOLFGANG, Steven, M. Reston, VA 20191 (US) RANDLE, Scot, R. St. Louis, MO 63129 (US) (74) Representative: Cockerton, Bruce Roger et al Carpmaels & Ransford, 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)