(19)

(11)

EP 1 781 702 A2

(12)

(88) Date of publication A3: 19.01.2006 (43) Date of publication: 09.05.2007 Bulletin 2007/19 (21) Application number: 05745014.0 (22) Date of filing: 18.05.2005

(51) International Patent Classification (IPC):  C07K 14/725(2006.01) G01N 33/68(2006.01) C12N 15/10(2006.01) (86) International application number: PCT/GB2005/001948 (87) International publication number: WO 2005/116074 (08.12.2005 Gazette 2005/49)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 26.05.2004 GB 0411771 (71) Applicant: Avidex Ltd. Abingdon OX14 4RX (GB)

(72) Inventors: BOULTER, J.M., Cardiff Univeristy , Dep Biochem Health Park, Cardiff CF14 4XN (GB) ANDERSEN, Torben, Bent DK-8660 Skanderborg (DK) JAKOBSEN, Bent, Karsten, c/o Avidex Ltd Oxfordshire OX14 4RX (GB) MOLLOY, Peter, Eamon, c/o Avidex Ltd Oxfordshire OX14 4RX (GB) LI, Yi, c/o Avidex Ltd Oxfordshire OX14 4RX (GB) (74) Representative: Walls, Alan James  Avidex Ltd, 57C Milton Park Abingdon, Oxfordshire OX14 4RX Abingdon, Oxfordshire OX14 4RX (GB)