(19)

(11)

EP 1 781 823 A2

(12)

(88) Date of publication A3: 18.05.2006 (43) Date of publication: 09.05.2007 Bulletin 2007/19 (21) Application number: 05791000.2 (22) Date of filing: 14.07.2005

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) A01K 67/027(2006.01) C12N 15/63(2006.01) (86) International application number: PCT/US2005/025056 (87) International publication number: WO 2006/019954 (23.02.2006 Gazette 2006/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 16.07.2004 US 588343 P (71) Applicant: Biogen Idec MA Inc. Cambridge, Massachusetts 02142 (US)	(72) Inventors: CHEUNG, Hung-Kam Medford, MA 02155 (US) LING, Leona, E. Winchester, MA 01890 (US) PARR, Michael Cambridge, MA 02139 (US) BARSOUM, James, G. Lexington, MA 02421 (US) (74) Representative: Pohlman, Sandra M.  df-mp, Dörries, Frank-Molnia & Pohlman, Triftstrasse 13 80538 München 80538 München (DE)