(19)

(11)

EP 1 784 212 A2

(12)

(43) Date of publication: 16.05.2007 Bulletin 2007/20 (21) Application number: 05858353.5 (22) Date of filing: 01.07.2005

(51) International Patent Classification (IPC):  A61K 39/085(2006.01) (86) International application number: PCT/US2005/023511 (87) International publication number: WO 2007/018482 (15.02.2007 Gazette 2007/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 06.07.2004 US 585698 P (71) Applicant: Merck & Co., Inc. Rahway, NJ 07065-0907 (US)	(72) Inventors: MONTGOMERY, Donna,I Rahway, NJ 07065-0907 (US) JANSEN, Kathrin, Ute Rahway, NJ 07065-0907 (US) ANDERSON, Annaliesa, S. Rahway, NJ 07065-0907 (US) MACCLEMENTS, William, I Rahway, NJ 07065-0907 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc. European Patent Department Hertford Road Hoddesdon Hertfordshire EN11 9BU Hoddesdon Hertfordshire EN11 9BU (GB)