(19)

(11)

EP 1 784 499 A2

(12)

(88) Date of publication A3: 08.06.2006 (43) Date of publication: 16.05.2007 Bulletin 2007/20 (21) Application number: 05804464.5 (22) Date of filing: 20.07.2005

(51) International Patent Classification (IPC):  C12Q 1/00(2006.01) G01N 21/00(2006.01) G01N 21/75(2006.01) G01N 33/44(2006.01) G01N 33/53(2006.01) G01N 33/574(2006.01) G01N 1/00(2006.01) G01N 21/62(2006.01) G01N 24/00(2006.01) G01N 33/48(2006.01) G01N 33/537(2006.01) (86) International application number: PCT/US2005/025632 (87) International publication number: WO 2006/020302 (23.02.2006 Gazette 2006/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 23.07.2004 US 590350 P (71) Applicant: Eastern Virginia Medical School Norfolk, VA 23507 (US)	(72) Inventors: VLAHOU, Antonia Norfolk, Virginia 23507 (US) SEMMES, O. John Newport News, Virginia 23501 (US) (74) Representative: Plougmann & Vingtoft A/S  Sundkrogsgade 9, P.O. Box 831 2100 Copenhagen Ø 2100 Copenhagen Ø (DK)