(19)

(11)

EP 1 786 918 A2

(12)

(88) Date of publication A3: 12.10.2006 (43) Date of publication: 23.05.2007 Bulletin 2007/21 (21) Application number: 05773142.4 (22) Date of filing: 18.07.2005

(51) International Patent Classification (IPC):  C12P 21/08(2006.01) C07K 16/28(2006.01) C07K 16/46(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2005/025472 (87) International publication number: WO 2006/020258 (23.02.2006 Gazette 2006/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 17.07.2004 US 588688 P (71) Applicant: IMCLONE SYSTEMS, INC. New York, NY 10014 (US)	(72) Inventor: ZHU, Zhenping Oakland, NJ 07436 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)