(19)

(11)

EP 1 789 451 A2

(12)

(88) Date of publication A3: 12.10.2006 (43) Date of publication: 30.05.2007 Bulletin 2007/22 (21) Application number: 05784935.8 (22) Date of filing: 09.08.2005

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C07H 21/04(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2005/028413 (87) International publication number: WO 2006/020706 (23.02.2006 Gazette 2006/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 12.08.2004 US 916840 12.08.2004 US 26116 02.02.2005 US 49536 (71) Applicant: Dyax Corporation Cambridge, MA 02139 (US)	(72) Inventors: WOOD, Clive R. Cambridge, MA 02138 (US) DRANSFIELD, Daniel T. Hanson, MA 02341 (US) PIETERS, Henk NL-6227 EV Maastricht (NL) HOET, Rene NL-6226 CV Mastricht (NL) HUFTON, Simon E. Lancs BB7 2AG (GB) (74) Representative: Wichmann, Hendrik  Isenbruck Bösl Hörschler Wichmann Huhn Prinzregentenstrasse 68 81675 München 81675 München (DE)