(19)
(11) EP 1 791 567 A2

(12)

(43) Date of publication:
06.06.2007 Bulletin 2007/23

(21) Application number: 05786618.8

(22) Date of filing: 10.08.2005
(51) International Patent Classification (IPC): 
A61K 48/00(2006.01)
A61K 31/675(2006.01)
(86) International application number:
PCT/US2005/028550
(87) International publication number:
WO 2006/020768 (23.02.2006 Gazette 2006/08)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated Extension States:
AL BA HR MK YU

(30) Priority: 10.08.2004 US 600703 P

(71) Applicant: Alnylam Pharmaceuticals Inc.
Cambridge, MA 02142 (US)

(72) Inventors:
  • MANOHARAN, Muthiah
    Weston, MA 02493 (US)
  • KESAVAN, Venkitasamy
    Woburn, MA 01801 (US)
  • RAJEEV, Kallanthottathil G.
    Cambridge, MA 02140 (US)

(74) Representative: Ruffles, Graham Keith et al
Marks & Clerk 66-68 Hills Road
Cambridge CB2 1LA
Cambridge CB2 1LA (GB)

   


(54) CHEMICALLY MODIFIED OLIGONUCLEOTIDES