(19)

(11)

EP 1 791 827 A1

(12)

(43) Date of publication: 06.06.2007 Bulletin 2007/23 (21) Application number: 05775527.4 (22) Date of filing: 26.08.2005

(51) International Patent Classification (IPC):  C07D 401/06(2006.01) C07D 407/14(2006.01) A61K 31/502(2006.01) C07D 401/14(2006.01) C07D 409/14(2006.01) A61P 31/20(2006.01) (86) International application number: PCT/GB2005/003343 (87) International publication number: WO 2006/021801 (02.03.2006 Gazette 2006/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 26.08.2004 GB 0419072 27.08.2004 US 604956 P (71) Applicant: Kudos Pharmaceuticals Limited Cambridge, Cambridgeshire CB4 0WG (GB)

(72) Inventors: JAVAID, Muhammad H., C/O Kudos Pharmaceuticals Ltd Cambridge, Cambridgeshire CB4 0WG (GB) SMITH, Graeme C.M., C/O Kudos Pharmaceuticals Ltd. Cambridge, Cambridgeshire CB4 0WG (GB) MARTIN, Niall M.B., C/O Kudos Pharmaceuticals Ltd. Cambridge, Cambridgeshire CB4 0WG (GB) GOMEZ, Sylvie C/O Kudos Pharmaceuticals Limited Cambridge, Cambridgeshire CB4 0WG (GB) LOH, Vincent M.L., Jr., Kudos Pharmaceuticals Ltd. Cambridge, Cambridgeshire CB4 0WG (GB) COCKCROFT, Xiao-Ling F., Kudos Pharmaceuticals Ltd Cambridge, Cambridgeshire CB4 0WG (GB) FORTE, Stefano, C/O Kudos Pharmaceuticals Limited Cambridge, Cambridgeshire CB4 0WG (GB) MENEAR, Keith A., C/O Kudos Pharmaceuticals Ltd. Cambridge, Cambridgeshire CB4 0WG (GB) MATTHEWS, Ian T.W., C/O Kudos Pharmaceuticals Ltd. Cambridge, Cambridgeshire CB4 0WG (GB) (74) Representative: Watson, Robert James et al Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)