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(11)

EP 1 793 843 A1

(12)

(43) Date of publication: 13.06.2007 Bulletin 2007/24 (21) Application number: 05805719.1 (22) Date of filing: 30.09.2005

(51) International Patent Classification (IPC):  A61K 38/12(2006.01) C07F 9/553(2006.01) A61P 35/00(2006.01) A61K 31/675(2006.01) C07K 5/12(2006.01) (86) International application number: PCT/US2005/035246 (87) International publication number: WO 2006/039527 (13.04.2006 Gazette 2006/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 30.09.2004 US 614800 P (71) Applicant: Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Rockville, Maryland 20852 (US)	(72) Inventors: BURKE, JR., Terrence R. Bethesda MD 20817 (US) SHI, Zhen-Dan Bethesda MD 20817 (US) OISHI, Shinya Kyoto 606-8393 (JP) LIU, Fa Frederick, MD 21701 (US) (74) Representative: Hoechst, Bruno Werner et al Bohest Intellectual Property A. Braun Braun Héritier Eschmann AG Holbeinstrasse 36-38 4051 Basel 4051 Basel (CH)