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EP 1 796 662 A2

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(88) Date of publication A3: 04.05.2006 (43) Date of publication: 20.06.2007 Bulletin 2007/25 (21) Application number: 05803872.0 (22) Date of filing: 30.08.2005

(51) International Patent Classification (IPC):  A61K 31/381(2006.01) A61K 31/4155(2006.01) A61K 31/519(2006.01) A61P 31/18(2006.01) A61K 31/422(2006.01) A61K 31/4709(2006.01) A61P 31/14(2006.01) (86) International application number: PCT/US2005/030846 (87) International publication number: WO 2006/026619 (09.03.2006 Gazette 2006/10)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 30.08.2004 US 605165 P (71) Applicant: The Government of the U.S.A., as repr. by the Secretary, Dept. of Health & Human Services, the Nat. Inst. of Health Rockville, MD 20852 (US)

(72) Inventors: BEUTLER, John Union Bridge, MD 20852 (US) LEGRICE, Stuart, F., J. Poolesville, MD 20837 (US) BUDIHAS, Scott, R. Frederick, MD 21703 (US) WAMIRU, Anthony Germantown, MD 20874 (US) GARDELLA, Roberta Frederick, MD 21701 (US) WILSON, Jennifer Frederick, MD 21701 (US) GONCHAROVA, Katya Ijamsville, MD 21754 (US) (74) Representative: Adam, Holger  Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)