(19)

(11)

EP 1 796 680 A2

(12)

(88) Date of publication A3: 08.09.2006 (43) Date of publication: 20.06.2007 Bulletin 2007/25 (21) Application number: 05798310.8 (22) Date of filing: 14.09.2005

(51) International Patent Classification (IPC):  A61K 31/59(2006.01) A61K 38/00(2006.01) (86) International application number: PCT/US2005/033421 (87) International publication number: WO 2006/032053 (23.03.2006 Gazette 2006/12)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 14.09.2004 US 609651 P 28.10.2004 US 623649 P 28.10.2004 US 623744 P 06.07.2005 US 697258 P (71) Applicant: Teva Pharmaceutical Industries Ltd 49131 Petah Tiqva (IL)	(72) Inventors: SCHWARTZ, Aharon Jerusalem (IL) LADKANI, David Kiriat Yovel 96704, Jerusalem (IL) MAZOR, Zeev Jerusalem 97886 (IL) ACHIRON, Anat Tel Baruch (IL) PINCHASI, Irit Ra'anana (IL) KOFLER, Dina Zoran 42823 (IL) HAYARDENY, Liat Tel-Aviv 69391 (IL) (74) Representative: Wong, Kit Yee et al D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)