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(11)

EP 1 799 637 A1

(12)

(43) Date of publication: 27.06.2007 Bulletin 2007/26 (21) Application number: 05797852.0 (22) Date of filing: 19.09.2005

(51) International Patent Classification (IPC):  C07C 311/19(2006.01) C07D 211/08(2006.01) A61K 31/40(2006.01) C07D 207/48(2006.01) A61K 31/18(2006.01) A61K 31/445(2006.01) (86) International application number: PCT/US2005/033659 (87) International publication number: WO 2006/036664 (06.04.2006 Gazette 2006/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 23.09.2004 US 612921 P (71) Applicant: Amgen, Inc Thousand Oaks CA 91320 (US)

(72) Inventors: ASKEW, JR, Ben, C. Marshfield, MA 02050 (US) AYA, Toshihiro Thousand Oaks, CA 91360 (US) BISWAS, Kaustav Calabasas, CA 91302 (US) CAI, Guolin Thousand Oaks, CA 91362 (US) CHEN, Jian, J. Newbury Park, CA 91320 (US) FOTSCH, Christopher, H. Thousand Oaks, CA 91360 (US) HAN, Nianhe Thousand Oaks, CA 91320 (US) HUMAN, Jason, Brooks Gastonia, NC 28054 (US) LI, Aiwen Westlake Village, CA 91362 (US) LIU, Qingyian Camarillo, California 93012 (US) PETERKIN, Tanya Woodland Hills, CA 91364 (US) QIAN, Wenyuan Camarillo, CA 93010 (US) RIAHI, Babak Woodland Hills, CA 91367 (US) YUAN, Chester, Chenguang Newbury Park, CA 91320 (US) ZHU, Jiawang Thousand Oaks, CA 91320 (US) (74) Representative: HOFFMANN EITLE  Patent- und Rechtsanwälte Arabellastrasse 4 81925 München 81925 München (DE)