(19)

(11)

EP 1 802 314 A2

(12)

(88) Date of publication A3: 21.12.2006 (43) Date of publication: 04.07.2007 Bulletin 2007/27 (21) Application number: 05796529.5 (22) Date of filing: 13.09.2005

(51) International Patent Classification (IPC):  A61K 31/70(2006.01) (86) International application number: PCT/US2005/032312 (87) International publication number: WO 2006/031683 (23.03.2006 Gazette 2006/12)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 15.09.2004 US 941025 20.09.2004 US 944269 26.10.2004 US 972777 (71) Applicant: THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY Cambridge, MA 02139 (US)	(72) Inventors: WURTMAN, Richard, J. Boston, MA 02116 (US) WATKINS, Carol Cambridge, MA 02139 (US) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)