(19)

(11)

EP 1 804 831 A2

(12)

(88) Date of publication A3: 10.08.2006 (43) Date of publication: 11.07.2007 Bulletin 2007/28 (21) Application number: 05811815.9 (22) Date of filing: 14.09.2005

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) A61K 39/385(2006.01) A61K 39/02(2006.01) A61K 38/17(2006.01) (86) International application number: PCT/US2005/032682 (87) International publication number: WO 2006/036550 (06.04.2006 Gazette 2006/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 24.09.2004 US 949667 13.09.2005 US 223945 (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA Philadelphia, PA 19104-6283 (US)	(72) Inventors: PATERSON, Yvonne Philadelphia, PA 19143 (US) SINGH, RESHMA PHILADELPhia, PA 19106 (US) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)