(19)

(11)

EP 1 805 132 A2

(12)

(88) Date of publication A3: 23.11.2006 (43) Date of publication: 11.07.2007 Bulletin 2007/28 (21) Application number: 05857821.2 (22) Date of filing: 05.10.2005

(51) International Patent Classification (IPC):  C07C 233/05(2006.01) C07D 211/22(2006.01) C07D 277/04(2006.01) A61K 31/195(2006.01) A61K 31/425(2006.01) C07C 229/00(2006.01) C07D 241/04(2006.01) A61K 31/165(2006.01) A61K 31/445(2006.01) A61K 31/495(2006.01) (86) International application number: PCT/US2005/035743 (87) International publication number: WO 2006/110173 (19.10.2006 Gazette 2006/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 05.10.2004 US 616065 P 22.09.2005 US 719729 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia, PA 19101 (US)	(72) Inventors: BOEHM, Jeffrey, C. King of Prussia, PA 19406 (US) CALLAHAN, James, Francis King of Prussia, PA 19406 (US) WAN, Zehong King of Prussia, PA 19406 (US) YAN, Hongxing King of Prussia, PA 19406 (US) (74) Representative: Shore, Andrew David et al GlaxoSmithKline Corporate Intellectual Property (CN 925.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)