(19)

(11)

EP 1 805 180 A1

(12)

(43) Date of publication: 11.07.2007 Bulletin 2007/28 (21) Application number: 05810272.4 (22) Date of filing: 20.10.2005

(51) International Patent Classification (IPC):  C07D 473/04(2006.01) A61K 31/522(2006.01) C07D 473/06(2006.01) A61P 9/00(2006.01) (86) International application number: PCT/EP2005/011376 (87) International publication number: WO 2006/045565 (04.05.2006 Gazette 2006/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 22.10.2004 GB 0423568 10.12.2004 GB 0427079 (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia, PA 19101 (US)	(72) Inventors: HATLEY, Richard Jonathan Daniel, GlaxoSmithKline Stevenage Hertfordshire SG1 2NY (GB) PINTO, Ivan Leo, GlaxoSmithKline Stevenage Hertfordshire SG1 2NY (GB) (74) Representative: Reed, Michael Antony et al GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)