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(11)

EP 1 805 220 A1

(12)

(43) Date of publication: 11.07.2007 Bulletin 2007/28 (21) Application number: 04795965.5 (22) Date of filing: 13.10.2004

(51) International Patent Classification (IPC):  C07K 16/24(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2004/034878 (87) International publication number: WO 2006/043954 (27.04.2006 Gazette 2006/17)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR MK (71) Applicant: GENENTECH, INC. South San Francisco, CA 94080-4990 (US)	(72) Inventors: ASHKENAZI, Avi San Mateo, CA 94402 (US) PITTI, Robert El Cerrito, CA 94530 (US) WU, Thomas San Francisco, CA 94110 (US) ZHANG, Zemin Foster City, CA 94404 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)