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EP 1 805 297 A2

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(88) Date of publication A3: 02.11.2006 (43) Date of publication: 11.07.2007 Bulletin 2007/28 (21) Application number: 05825074.7 (22) Date of filing: 29.09.2005

(51) International Patent Classification (IPC):  C12N 5/00(2006.01) C12N 5/08(2006.01) A01N 65/00(2006.01) C12N 5/02(2006.01) A01N 63/00(2006.01) (86) International application number: PCT/US2005/035030 (87) International publication number: WO 2006/037103 (06.04.2006 Gazette 2006/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 30.09.2004 US 957171 (71) Applicants: The Trustees of Columbia University in the City of New York New York, NY 10027-6699 (US) The Research Foundation of State University of New York Stony Brook, NY 11794 (US)

(72) Inventors: DORONIN, Sergey, V. Stony Brook, NY 11790 (US) GAUDETTE, Glenn Holden, MA 01520 (US) ROBINSON, Richard, B. Cresskill, NJ 07626 (US) ROSEN, Michael, R. New York, NY 10028 (US) COHEN, Ira, S. Stony Brook, NY 11790 (US) BRINK, Peter, R. Setauket, NY 11733 (US) (74) Representative: Pohlman, Sandra M. et al df-mp, Dörries, Frank-Molnia & Pohlman, Triftstrasse 13 80538 München 80538 München (DE)