(19)

(11)

EP 1 805 322 A1

(12)

(43) Date of publication: 11.07.2007 Bulletin 2007/28 (21) Application number: 05811858.9 (22) Date of filing: 14.10.2005

(51) International Patent Classification (IPC):  C12Q 1/26(2006.01) G01N 33/53(2006.01) C12Q 1/00(2006.01) (86) International application number: PCT/US2005/036983 (87) International publication number: WO 2006/044633 (27.04.2006 Gazette 2006/17)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 15.10.2004 US 966983 03.12.2004 US 4477 (71) Applicant: GENERAL ATOMICS San Diego, CA 92186-5608 (US)	(72) Inventor: YUAN, Chong-Sheng San Diego, CA 92130 (US) (74) Representative: Laufer, Gabriele et al Witte, Weller & Partner Patentanwälte Postfach 10 54 62 70047 Stuttgart 70047 Stuttgart (DE)