(19)

(11)

EP 1 809 322 A2

(12)

(88) Date of publication A3: 31.05.2007 (43) Date of publication: 25.07.2007 Bulletin 2007/30 (21) Application number: 05807509.4 (22) Date of filing: 03.10.2005

(51) International Patent Classification (IPC):  A61K 39/07(2006.01) A61K 39/02(2006.01) C07K 1/00(2006.01) A61K 39/00(2006.01) A61K 38/00(2006.01) C07K 2/00(2006.01) (86) International application number: PCT/US2005/035722 (87) International publication number: WO 2006/039707 (13.04.2006 Gazette 2006/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 01.10.2004 US 614555 P (71) Applicant: Van Andel Research Institute Grand Rapids, MI 49503 (US)	(72) Inventor: DUESBERY, Nicholas, S. Grand Rapids, MI 49503 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)