(19)

(11)

EP 1 809 351 A2

(12)

(88) Date of publication A3: 29.06.2006 (43) Date of publication: 25.07.2007 Bulletin 2007/30 (21) Application number: 05810234.4 (22) Date of filing: 28.09.2005

(51) International Patent Classification (IPC):  A61M 5/00(2006.01) A61M 5/31(2006.01) A61K 49/18(2006.01) A61K 51/12(2006.01) (86) International application number: PCT/US2005/035156 (87) International publication number: WO 2006/037124 (06.04.2006 Gazette 2006/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 28.09.2004 US 613907 P (71) Applicant: MALLINCKRODT, INC. St. Louis Missouri 63134 (US)	(72) Inventors: PERIASAMY, Muthunadar, P. Chesterfield, Missouri 63017 (US) HAGEN, William, A. O'Fallon, Missouri 63366 (US) MAHONEY, Michael, R. Lake St. Louis, Missouri 63367 (US) (74) Representative: Cockerton, Bruce Roger et al Carpmaels & Ransford, 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)