(19)

(11)

EP 1 809 606 A1

(12)

(43) Date of publication: 25.07.2007 Bulletin 2007/30 (21) Application number: 05802078.5 (22) Date of filing: 10.11.2005

(51) International Patent Classification (IPC):  C07D 215/52(2006.01) A61P 25/18(2006.01) A61K 31/47(2006.01) A61P 25/24(2006.01) (86) International application number: PCT/EP2005/012207 (87) International publication number: WO 2006/050991 (18.05.2006 Gazette 2006/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 12.11.2004 GB 0425077 (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19101 (US)

(72) Inventors: BRADLEY, Daniel Marcus, GlaxoSmithKline Harlow, Essex CM19 5AW (GB) PORTER, Roderick Alan, GlaxoSmithKline Harlow, Essex CM19 5AW (GB) SMITH, Paul William, GlaxoSmithKline Harlow, Essex CM19 5AW (GB) STEAD, Rachel Elizabeth Anne, GlaxoSmithKline Harlow, Essex CM19 5AW (GB) VONG, Antonio Kuok Keong, GlaxoSmithKline Harlow, Essex CM19 5AW (GB) (74) Representative: Dolton, Peter Irving Ernest et al GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)