(19)
(11) EP 1 809 626 A2

(12)

(88) Date of publication A3:
08.06.2006

(43) Date of publication:
25.07.2007 Bulletin 2007/30

(21) Application number: 05812516.2

(22) Date of filing: 04.10.2005
(51) International Patent Classification (IPC): 
C07D 451/06(2006.01)
C07D 451/04(2006.01)
A61P 3/04(2006.01)
 C07D 451/02(2006.01)
A61K 31/46(2006.01)
(86) International application number:
PCT/US2005/035457
(87) International publication number:
WO 2006/044174 (27.04.2006 Gazette 2006/17)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 13.10.2004 US 618292 P

(71) Applicant: NEUROGEN CORPORATION
Branford, CT 06405 (US)

(72) Inventors:
  • CHENARD, Bertrand, L
    Waterford, CT 06385 (US)
  • GHOSH, Manuka
    Madison, CT 06443 (US)
  • DOLLER, Dario
    Wallingford, CT 06492 (US)
  • HUTCHISON, Alan, J.
    Madison, CT 06443 (US)
  • LI, Guiying
    Branford, CT 06405 (US)

(74) Representative: Smaggasgale, Gillian Helen 
W.P. Thompson & Co, 55 Drury Lane
London WC2B 5SQ
London WC2B 5SQ (GB)

   


(54) ARYL SUBSTITUTED 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR