(19)

(11)

EP 1 809 632 A2

(12)

(88) Date of publication A3: 17.08.2006 (43) Date of publication: 25.07.2007 Bulletin 2007/30 (21) Application number: 05800579.4 (22) Date of filing: 17.10.2005

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61K 31/519(2006.01) A61P 9/00(2006.01) A61P 15/00(2006.01) C07D 519/00(2006.01) A61P 9/12(2006.01) A61P 25/00(2006.01) A61P 3/00(2006.01) (86) International application number: PCT/IB2005/003326 (87) International publication number: WO 2006/046135 (04.05.2006 Gazette 2006/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 28.10.2004 US 622941 P (71) Applicant: Pharmacia & Upjohn Company LLC Kalamazoo, MI 49001 (US)

(72) Inventors: ACKER, Brad Alan, Pfizer Global R&D Chesterfield, MO 63017-1732 (US) HUGHES, Robert Owen, Pfizer Global R&D Chesterfield, MO 63017-1732 (US) JACOBSEN, Eric John, Pfizer Global R&D Chesterfield, MO 63017-1732 (US) LU, Hwang-Fun, Pfizer Global R&D Chesterfield, MO 63017-1732 (US) ROGERS, Thomas Edward, Pfizer Global R&D Chesterfield, MO 63017-1732 (US) TOLLEFSON, Michael Brent, Pfizer Global R&D Chesterfield, MO 63017-1732 (US) WALKER, John Keith, Pfizer Global R&D Chesterfield, MO 63017-1732 (US) (74) Representative: Kingsbury, Oliver William et al Pfizer Limited European Patent Department Ramsgate Road Sandwich Kent CT13 9NJ Sandwich Kent CT13 9NJ (GB)