(19)

(11)

EP 1 815 022 A2

(12)

(88) Date of publication A3: 08.09.2006 (43) Date of publication: 08.08.2007 Bulletin 2007/32 (21) Application number: 05849672.0 (22) Date of filing: 21.11.2005

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) C07H 21/02(2006.01) C07H 21/04(2006.01) (86) International application number: PCT/US2005/042407 (87) International publication number: WO 2006/058048 (01.06.2006 Gazette 2006/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 22.11.2004 US 630320 P 04.05.2005 US 678165 P 18.11.2005 US 283481 18.11.2005 US  18.11.2005 US  18.11.2005 US  (71) Applicant: Dharmacon, Inc. Lafayette, CO 80026 (US)	(72) Inventors: ROBERTSON, Barbara Boulder, CO 80304 (US) LEAKE, Devin Denver, CO 80222 (US) ROBINSON, Kathryn Golden, CO 80403 (US) MARSHALL, William, S. Boulder, CO 80303 (US) KHVOROVA, Anastasia Boulder, CO 80305 (US) (74) Representative: Whitaker, Iain Mark et al Scott & York 45 Grosvenor Road St Albans Hertfordshire AL1 3AW St Albans Hertfordshire AL1 3AW (GB)