(19)

(11)

EP 1 817 050 A2

(12)

(88) Date of publication A3: 16.11.2006 (43) Date of publication: 15.08.2007 Bulletin 2007/33 (21) Application number: 05826021.7 (22) Date of filing: 05.12.2005

(51) International Patent Classification (IPC):  A61K 38/30(2006.01) C12N 5/06(2006.01) (86) International application number: PCT/US2005/043856 (87) International publication number: WO 2006/060753 (08.06.2006 Gazette 2006/23)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 03.12.2004 US 632619 P 18.02.2005 US 654080 P 01.11.2005 US 731862 P (71) Applicant: RHODE ISLAND HOSPITAL Providence, RI 02903 (US)	(72) Inventors: DE LA MONTE, Suzanne, Marie East Greenwich, Rhode Island 02818 (US) WANDS, Jack, Raymond East Greenwich, Rhode Island 02818 (US) (74) Representative: Schlich, George William et al Schlich & Co 34 New Road Littlehampton West Sussex BN17 5AT Littlehampton West Sussex BN17 5AT (GB)