(19)

(11)

EP 1 825 265 A2

(12)

(88) Date of publication A3: 17.08.2006 (43) Date of publication: 29.08.2007 Bulletin 2007/35 (21) Application number: 05856162.2 (22) Date of filing: 09.12.2005

(51) International Patent Classification (IPC):  G01N 33/53(2006.01) (86) International application number: PCT/US2005/044578 (87) International publication number: WO 2006/063213 (15.06.2006 Gazette 2006/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 10.12.2004 US 634816 P (71) Applicant: University of Maryland, Baltimore Baltimore, Maryland 21201-1627 (US)	(72) Inventors: GONG, Da-wei Olney, Maryland 20832 (US) SHULDINER, Alan Columbia, Maryland 21044 (US) YANG, Rongze Baltimore, Maryland 21229 (US) FRIED, Susan Baltimore, Maryland 21231 (US) (74) Representative: Graf von Stosch, Andreas  Patentanwälte Bosch, Graf v. Stosch, Jehle Flüggenstrasse 13 80639 München 80639 München (DE)