(19)

(11)

EP 1 827 424 A1

(12)

(43) Date of publication: 05.09.2007 Bulletin 2007/36 (21) Application number: 05814002.1 (22) Date of filing: 09.12.2005

(51) International Patent Classification (IPC):  A61K 31/4184(2006.01) A61P 9/12(2006.01) A61K 31/5415(2006.01) (86) International application number: PCT/EP2005/013224 (87) International publication number: WO 2006/063737 (22.06.2006 Gazette 2006/25)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 17.12.2004 US 637062 P (71) Applicants: Boehringer Ingelheim International GmbH 55216 Ingelheim am Rhein (DE) AT BE BG CH CY CZ DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV  Boehringer Ingelheim Pharma GmbH & Co. KG 55216 Ingelheim (DE) DE	(72) Inventors: SCHUMACHER, Helmut E. 55218 Ingelheim am Rhein (DE) BÖHM, Peter 55543 Bad Kreuznach (DE) RIEDEL, Axel 88437 Maselheim (DE) (74) Representative: Hammann, Heinz et al Boehringer Ingelheim GmbH Binger Strasse 173 55216 Ingelheim am Rhein 55216 Ingelheim am Rhein (DE)