(19)

(11)

EP 1 827 486 A2

(12)

(88) Date of publication A3: 04.01.2007 (43) Date of publication: 05.09.2007 Bulletin 2007/36 (21) Application number: 05823713.2 (22) Date of filing: 21.12.2005

(51) International Patent Classification (IPC):  A61K 38/43(2006.01) C12N 9/00(2006.01) (86) International application number: PCT/EP2005/057061 (87) International publication number: WO 2006/067198 (29.06.2006 Gazette 2006/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 22.12.2004 EP 04106903 (71) Applicants: Direvo Biotech AG 50829 Köln (DE) Voetsmeier, Christian 50829 50829 Köln (DE)

(72) Inventors: HAUPTS, Ulrich, c/o Direvo Biotech Ag 50829 Köln (DE) KOLTERMANN, Andre, c/o Direvo Biotech Ag 50829 Köln (DE) SCHEIDIG, Andreas, c/o Direvo Biotech Ag 50829 Köln (DE) KETTLING, Ulrich, c/o Direvo Biotech Ag 50829 Köln (DE) COCO, Wayne Michael, c/o Direvo Biotech Ag 50829 Köln (DE) (74) Representative: Helbing, Jörg  Patentanwälte von Kreisler-Selting-Werner, Postfach 10 22 41 50462 Köln 50462 Köln (DE)