(19)

(11)

EP 1 828 161 A2

(12)

(88) Date of publication A3: 23.11.2006 (43) Date of publication: 05.09.2007 Bulletin 2007/36 (21) Application number: 05819231.1 (22) Date of filing: 06.12.2005

(51) International Patent Classification (IPC):  C07D 319/18(2006.01) (86) International application number: PCT/EP2005/056500 (87) International publication number: WO 2006/061372 (15.06.2006 Gazette 2006/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 07.12.2004 EP 04106350 07.12.2004 US 633449 P (71) Applicant: Solvay Pharmaceuticals B.V. 1381 CP Weesp (NL)

(72) Inventors: VAN HES, Roelof Solvay Pharmaceuticals B.V. C.J. van Houtenlaan 36 NL-1381 CP WEESP (NL) SMID, Pieter Solvay Pharmaceuticals B.V. C.J. van Houtenlaan 36 NL-1381 CP Weesp (NL) KRUSE, Cornelis G. Solvay Pharmaceuticals B.V. C.J. van Houtenlaan 36 NL-1381 CP Weesp (NL) TULP, Martinus Th.M. Solvay Pharmaceuticals B.V. C.J. van Houtenlaan 36 NL-1381 CP Weesp (NL) (74) Representative: Hogenbirk, Marijke et al Octrooibureau Zoan B.V. P.O. Box 140 NL-1380 AC Weesp NL-1380 AC Weesp (NL)