(19)

(11)

EP 1 828 377 A2

(12)

(88) Date of publication A3: 22.03.2007 (43) Date of publication: 05.09.2007 Bulletin 2007/36 (21) Application number: 05850890.4 (22) Date of filing: 20.12.2005

(51) International Patent Classification (IPC):  C12N 5/10(2006.01) G01N 33/50(2006.01) (86) International application number: PCT/IB2005/054333 (87) International publication number: WO 2006/067742 (29.06.2006 Gazette 2006/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 23.12.2004 IT RM20040634 (71) Applicant: Universita' degli studi di Roma I-00173 Roma (IT)	(72) Inventors: GRAZIANI, Grazia I-00133 Roma (IT) VERGATI, Matteo I-00046 Grottaferrata RM (IT) (74) Representative: Germinario, Claudio et al Società Italiana Brevetti Piazza di Pietra 39 00186 Roma 00186 Roma (IT)