Treatment of neurodegenerative disease through intracranial delivery of short interfering RNA (siRNA)

(19)

(11)

EP 1 829 547 A3

(12)	EUROPEAN PATENT APPLICATION

(88)	Date of publication A3:
	12.09.2007 Bulletin 2007/37

(43)	Date of publication A2:
	05.09.2007 Bulletin 2007/36

(21)	Application number: 07003775.9

(22)	Date of filing: 26.11.2003

(51)

International Patent Classification (IPC):

A61K 31/713^(2006.01)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

(30)

Priority:

26.11.2002 US 429387 P
03.02.2003 US 444614 P

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	03790026.3 / 1569662

(71)	Applicant: MEDTRONIC, INC.
	Minneapolis, Minnesota 55432-5604 (US)

(72)	Inventor:
	Kaemmerer, William F. Edina,MN 55435 (US)

(74)	Representative: Hughes, Andrea Michelle
	Frank B. Dehn & Co. St Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)

(54)	Treatment of neurodegenerative disease through intracranial delivery of short interfering RNA (siRNA)

(57) The present invention provides devices, small interfering RNA, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site in a brain, and discharging through the discharge portion of the catheter a predetermined dosage of at least one substance capable of inhibiting production of at least one neurodegenerative protein. The present invention also provides valuable small interfering RNA vectors, and methods for treating neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Spinocerebellar Ataxia Type 1, Type 2, Type 3, and/or dentatorubral-pallidoluysian atrophy.

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