(19)
(11) EP 1 831 239 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.09.2010 Bulletin 2010/37

(45) Mention of the grant of the patent:
24.03.2010 Bulletin 2010/12

(21) Application number: 05797368.7

(22) Date of filing: 11.10.2005
(51) International Patent Classification (IPC): 
C07J 53/00(2006.01)
 C07J 1/00(2006.01)
(86) International application number:
PCT/HU2005/000111
(87) International publication number:
WO 2006/059168 (08.06.2006 Gazette 2006/23)

(54)

A PROCESS FOR THE PREPARATION OF 17-HYDROXY-6 BETA, 7 BETA, 15 BETA, 16 BETA -BISMETHYLENE-17 ALPHA-PREGN-4-ENE-3-ONE-21-CARBOXYLIC ACID GAMMA-LACTONE AND KEY-INTERMEDIATES FOR THIS PROCESS

VERFAHREN ZUR HERSTELLUNG VON 17-HYDROXY-6 BETA, 7 BETA, 15 BETA,16 BETA-BISMETHYLEN-17ALPHA-PREGN-4-EN-3-ON-21-CARBONSÄURE GAMMA-LACTON UND SCHLÜSSELZWISCHENPRODUKTE FÜR DIESES VERFAHREN

PROCÉDÉ DE SYNTHÈSE DE LA GAMMA-LACTONE DE L'ACIDE 17-HYDROXY-6 BETA, 7 BETA, 15 BETA, 16 BETA -BISMÉTHYLÈNE -17 ALPHA- PREGN-4- ÈNE-3-ONE-21 CARBOXYLIQUE ET INTERMÉDIARIES-CLÉS DE CE PROCÉDÉ

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 30.11.2004 HU 0402466

(43) Date of publication of application:
12.09.2007 Bulletin 2007/37

(73) Proprietor: Richter Gedeon Nyrt.
1103 Budapest (HU)

(72) Inventors:
  • GÁLIK, György
    H-2730 Albertirsa (HU)
  • HORVÁTH, Judit
    H-1125 Budapest (HU)
  • SÖRÖS, Béla
    H-1161 Budapest (HU)
  • MAHÓ, Sándor
    H-1183 Budapest (HU)
  • TUBA, Zoltán
    H-1022 Budapest (HU)
  • BALOGH, Gábor
    H-1183 Budapest (HU)

(74) Representative: HOFFMANN EITLE 
Patent- und Rechtsanwälte Arabellastrasse 4
81925 München
81925 München (DE)


(56) References cited: : 
WO-A-98/25948
 WO-A-03/082894
   
  • K. PETZOLDT ET AL: "A Novel Synthetic Route to the Aldosterone-Antagonist Spironenone" ANGEWANDTE CHEMIE. INTERNATIONAL EDITION., vol. 22, no. 3, 1983, pages 406-407, XP002365035 DEWILEY VCH VERLAG, WEINHEIM.
  • D. BITTLER ET AL: "Synthesis of Spironenone - A Novel Highly Active Aldosterone Antagonist" ANGEWANDTE CHEMIE. INTERNATIONAL EDITION., vol. 21, no. 9, 1982, pages 696-697, XP002365036 DEWILEY VCH VERLAG, WEINHEIM.
  • NORMAN P ET AL: "CONTRACEPTIVE HORMONE REPLACEMENT THERAPY ALDOSTERONE ANTAGONIST PROGESTOGEN" DRUGS OF THE FUTURE, BARCELONA, ES, vol. 25, no. 12, December 2000 (2000-12), pages 1247-1256, XP000993474 ISSN: 0377-8282
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).