(19)

(11)

EP 1 831 244 A2

(12)

(88) Date of publication A3: 08.02.2007 (43) Date of publication: 12.09.2007 Bulletin 2007/37 (21) Application number: 05823581.3 (22) Date of filing: 14.12.2005

(51) International Patent Classification (IPC):  C07K 7/06(2006.01) (86) International application number: PCT/IT2005/000733 (87) International publication number: WO 2006/064530 (22.06.2006 Gazette 2006/25)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 15.12.2004 IT RM20040607 (71) Applicant: Biogen S.r.l. 00155 Roma (IT)	(72) Inventors: MELCHIORRI, Pietro, c/oBiogen S.r.l. I-00155 Roma (IT) NEGRI, Lucia, c/oBiogen S.r.l. I-00155 Roma (IT) ROCCHI, Raniero, c/oBiogen S.r.l. I-00155 Roma (IT) CIOCCA, Luigi, c/oBiogen S.r.l. I-00155 Roma (IT) (74) Representative: Germinario, Claudio  Società Italiana Brevetti Piazza di Pietra 39 00186 Roma 00186 Roma (IT)