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EP 1 833 797 A1

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(43) Date of publication: 19.09.2007 Bulletin 2007/38 (21) Application number: 06700329.3 (22) Date of filing: 06.01.2006

(51) International Patent Classification (IPC):  C07D 217/04(2006.01) C07D 209/48(2006.01) A61P 25/04(2006.01) C07D 401/12(2006.01) C07D 417/04(2006.01) C07D 413/04(2006.01) C07D 405/12(2006.01) A61K 31/4365(2006.01) A61K 31/472(2006.01) A61K 31/4035(2006.01) A61P 25/06(2006.01) A61K 31/4725(2006.01) A61K 31/5415(2006.01) A61K 31/538(2006.01) C07D 495/04(2006.01) (86) International application number: PCT/GB2006/000040 (87) International publication number: WO 2006/082354 (10.08.2006 Gazette 2006/32)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 07.01.2005 GB 0500300 (71) Applicant: VERNALIS (R&D) LTD Winnersh RG41 5UA (GB)

(72) Inventors: HAMLYN, Richard, Ionix Pharmaceuticals Limited Cambridge CB4 0PA (GB) HUCKSTEP, Mike, Ionix Pharmaceuticals Limited Cambridge CB4 0PA (GB) EARNSHAW, Christopher G., Ionix Pharm. Limited Cambridge CB4 0PA (GB) STOKES, Stephen, Ionix Pharmaceuticals Limited Cambridge CB4 0PA (GB) TICKLE, David, Ionix Pharmaceuticals Limited Cambridge CB4 0PA (GB) ALLART, Brigitte, Ionix Pharmaceuticals Limited Cambridge CB4 0PA (GB) BOYD, Joseph William, Ionix Pharm. Limited Cambridge CB4 0PA (GB) KNUTSEN, Lars Jacob S., Ionix Pharm. Limited Cambridge CB4 0PA (GB) LYNCH, Rosemary, Ionix Pharmaceuticals Limited Cambridge CB4 0PA (GB) PATIENT, Lee, Ionix Pharmaceuticals Limited Cambridge CB4 0PA (GB) (74) Representative: Walls, Alan James  Vernalis (R&D) Ltd Oakdene Court 613 Reading Road, Winnersh Wokingham, Berkshire RG41 5UA Wokingham, Berkshire RG41 5UA (GB)