(19)

(11)

EP 1 833 804 A1

(12)

(43) Date of publication: 19.09.2007 Bulletin 2007/38 (21) Application number: 05821963.5 (22) Date of filing: 23.12.2005

(51) International Patent Classification (IPC):  C07D 261/08(2006.01) A61K 31/4245(2006.01) A61P 25/22(2006.01) A61P 25/34(2006.01) C07D 271/06(2006.01) A61K 31/42(2006.01) A61P 25/18(2006.01) A61P 25/28(2006.01) C07D 261/04(2006.01) (86) International application number: PCT/SE2005/002037 (87) International publication number: WO 2006/071184 (06.07.2006 Gazette 2006/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 28.12.2004 US 639514 P (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventors: BROWN, Dean AstraZeneca Wilmington Wilmington, DE 19850-5437 (US) MCLAREN, Frances M AstraZeneca Wilmington Wilmington, DE 19850-5437 (US) SIMPSON, Thomas Richard AstraZeneca Wilmington Wilmington, DE 19850-5437 (US) (74) Representative: Wahlström, Stig Christer Gunnar  AstraZeneca Global Intellectual Property 151 85 Södertälje 151 85 Södertälje (SE)