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(11)

EP 1 833 836 A1

(12)

(43) Date of publication: 19.09.2007 Bulletin 2007/38 (21) Application number: 05849206.7 (22) Date of filing: 10.11.2005

(51) International Patent Classification (IPC):  C07D 513/14(2006.01) A61P 35/00(2006.01) A61P 37/02(2006.01) A61K 31/4365(2006.01) A61P 29/02(2006.01) (86) International application number: PCT/US2005/040726 (87) International publication number: WO 2006/053120 (18.05.2006 Gazette 2006/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 12.11.2004 US 627761 P (71) Applicant: Bristol-Myers Squibb Company Princeton, NJ 08543-4000 (US)

(72) Inventors: DYCKMAN, Alaric Lawrenceville, New Jersey 08648 (US) BELEMA, Makonen North Haven, Connecticut 06473 (US) GILL, Patrice Chateauguay, Québec J6K 4P7 (CA) KEMPSON, James Princeton, New Jersey 08540 (US) PITTS, William J. Newtown, Pennsylvania 18940 (US) QIU, Yuping Glastonbury, Connecticut 06033 (US) QUESNELLE, Claude Brossard, Québec J4X 1L3 (CA) SPERGEL, Steven H. Warrington, Pennsylvania 18976 (US) ZUSI, F. Christopher Hamden, Connecticut 06514 (US) (74) Representative: Beacham, Annabel Rose  Frank B. Dehn & Co. St Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)