(19)

(11)

EP 1 833 975 A2

(12)

(88) Date of publication A3: 03.08.2006 (43) Date of publication: 19.09.2007 Bulletin 2007/38 (21) Application number: 05849656.3 (22) Date of filing: 09.12.2005

(51) International Patent Classification (IPC):  C12N 15/864(2006.01) A61P 25/16(2006.01) A61K 48/00(2006.01) (86) International application number: PCT/US2005/044654 (87) International publication number: WO 2006/063247 (15.06.2006 Gazette 2006/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 09.12.2004 US 635356 P (71) Applicant: GENZYME CORPORATION Framingham, MA 01701 (US)	(72) Inventors: SANFTNER, Laura, McGee Alameda, California 94502-6541 (US) RIVERA, Victor, M. Alemeda, California 94502-6541 (US) (74) Representative: Adams, Harvey Vaughan John  Mathys & Squire 120 Holborn London EC1N 2SQ London EC1N 2SQ (GB)