(19)

(11)

EP 1 838 274 A1

(12)

(43) Date of publication: 03.10.2007 Bulletin 2007/40 (21) Application number: 05711722.8 (22) Date of filing: 19.01.2005

(51) International Patent Classification (IPC):  A61K 6/00(2006.01) (86) International application number: PCT/US2005/001839 (87) International publication number: WO 2006/078245 (27.07.2006 Gazette 2006/30)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (71) Applicants: Cincinnati Childrens's Hospital Medical Center Cincinnati, OH 45229-3039 (US) UNIVERSITY OF CINCINNATI Cincinnati, OH 45221-0623 (US)	(72) Inventors: HOATH, Steven B. Cincinnati, OH 45244 (US) PICKENS, William L. Cincinnati, OH 45223 (US) VISSCHER, Martha O. Cincinnati, OH 45246 (US) TANSIRIKONGKOL, Anyarporn Cincinnati, OH 45220 (US) WICKETT, Richard Randall Cincinnati, OH 45220 (US) (74) Representative: Arends, William Gerrit et al Lloyd Wise Commonwealth House 1-19 New Oxford Street London WC1A 1LW London WC1A 1LW (GB)