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EP 1 838 325 A1

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(43) Date of publication: 03.10.2007 Bulletin 2007/40 (21) Application number: 06700349.1 (22) Date of filing: 04.01.2006

(51) International Patent Classification (IPC):  A61K 31/554(2006.01) A61P 25/20(2006.01) A61P 25/30(2006.01) A61P 25/36(2006.01) A61P 25/00(2006.01) A61P 25/26(2006.01) A61P 25/32(2006.01) (86) International application number: PCT/SE2006/000009 (87) International publication number: WO 2006/073360 (13.07.2006 Gazette 2006/28)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 07.01.2005 US 642262 P 18.11.2005 US 737887 P 18.11.2005 US 737865 P 18.11.2005 US 737864 P (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)

(72) Inventors: DAVIS, Patricia C. AstraZeneca Wilmington Wilmington, DE 19850-5437 (US) GOLDSTEIN, Jeffrey M. AstraZeneca Wilmington Wilmington, DE 19850-5437 (US) GRIMM, Scott W. AstraZeneca Wilmington Wilmington, DE 19850-5437 (US) SUCKOW, Raymond F. West Patterson, NJ 07424 (US) WINTER, Helen R. AstraZeneca Wilmington Wilmington, DE 19850-5437 (US) (74) Representative: Bassil, Nicholas Charles et al Kilburn & Strode 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)