(19)

(11)

EP 1 844 044 A1

(12)

(43) Date of publication: 17.10.2007 Bulletin 2007/42 (21) Application number: 06701375.5 (22) Date of filing: 09.01.2006

(51) International Patent Classification (IPC):  C07D 417/14(2006.01) C07D 419/12(2006.01) A61K 31/415(2006.01) A61P 25/00(2006.01) C07D 417/12(2006.01) C07D 277/42(2006.01) A61K 31/426(2006.01) (86) International application number: PCT/EP2006/000090 (87) International publication number: WO 2006/074884 (20.07.2006 Gazette 2006/29)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 14.01.2005 EP 05100203 (71) Applicant: F.HOFFMANN-LA ROCHE AG 4070 Basel (CH)	(72) Inventors: BUETTELMANN, Bernd 79650 Schopfheim (DE) CECCARELLI, Simona, Maria. CH-4057 Basel (CH) JAESCHKE, Georg CH-4051 Basel (CH) KOLCZEWSKI, Sabine 79618 Rheinfelden (DE) PORTER, Richard, Hugh, Philip CH-4153 Reinach (CH) VIEIRA, Eric CH-4402 Frenkendorf (CH) (74) Representative: Braun, Axel  F.Hoffmann-La Roche AG Patent Department (PLP), 124 Grenzacherstrasse 4070 Basel 4070 Basel (CH)