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(11)

EP 1 844 052 A1

(12)

(43) Date of publication: 17.10.2007 Bulletin 2007/42 (21) Application number: 06710294.7 (22) Date of filing: 17.01.2006

(51) International Patent Classification (IPC):  C07D 495/04(2006.01) A61K 31/519(2006.01) A61P 7/02(2006.01) (86) International application number: PCT/IB2006/000172 (87) International publication number: WO 2006/079916 (03.08.2006 Gazette 2006/31)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 26.01.2005 US 647340 P 07.03.2005 US 659337 P (71) Applicant: Pharmacia & Upjohn Company LLC Kalamazoo, MI 49001-0199 (US)

(72) Inventors: ENNIS, Michael Dalton, Pfizer Global R & D Chesterfield, MO 63017-1732 (US) KORTUM, Steven Wade, Pfizer Global R & D Chesterfield, MO 63017-1732 (US) RAHMAN, Hayat, Pfizer Global R & D Chesterfield, MO 63017-1732 (US) SCHWEITZER, Barbara Ann, Pfizer Global R & D Chesterfield, MO 63017-1732 (US) TENBRINK, Ruth Elizabeth, Pfizer Global R & D Chesterfield, MO 63017-1732 (US) (74) Representative: Rudge, Andrew John  Pfizer Limited European Patent Department Ramsgate Road Sandwich CT13 9NJ Ramsgate Road Sandwich CT13 9NJ (GB)